Experimental design and statistical methods in biomedical experimentation

From ERAC Edu

Time: April 20 - 24, 2006

Place: University of Kuopio, Kuopio (Maps and connections)

Medistudia (the building number 3 on the map)

Tietoteknia (the building number 13 on the map)

Canthia (the building number 1 on the map)

Research Center Neulanen, Lecture room

Language: English

Course leader: Timo Nevalainen, University of Kuopio

Lecturers: David Lovell, University of Surrey, UK

Timo Nevalainen, University of Kuopio, Finland

Matti Viluksela, National Public Health Institute, Kuopio, Finland

Further information: timo.nevalainen at uku.fi

Time schedule:

Date	Lecture
Monday, April 20
Tietoteknia, TTA
9.15-9.30	Introduction to the course Timo Nevalainen
9.30-11.00	Nonstatistical aspects of design. Bias. Choice of animals and precision. Design of environment. Applicability. Practical randomisation. Case for Refinement and Reduction. Timo Nevalainen
11.15-12.00	Designs for regulatory safety evaluation of chemicals Matti Viluksela
15.00-17.00	Group work on participants' own design and statistics problems
Tuesday, April 21
Medistudia, ML3
9.15-12.00	How Statistics can help when running experiments? Basic statistical ideas. Signal and noise. Randomness and chance. Sources of variability. Use of graphical tools in evaluation of data. Determination of sample size. Basic principles of design in animal studies. Hypothesis. Bias. Experimental unit. Controls. Replication. Randomisation. Independent and dependent variables. Blocking. Software available for statistics. How to present data. David Lovell
Canthia, S9
13.00-17.00	Practical MINITAB exercises on day's topics David Lovell
Wednesday, April 22
Research Center Neulanen, Lecture room
9.15-12.00	Basic statistical tests. t-tests and confidence intervals. One-way ANOVA. Two-way ANOVA and factor interactions. Interpretation.
Tietoteknia, TTA
13.00-15.00	Designs for refinement and scoring adverse effects. Refinement, scoring adverse effect, humane endpoints. Workshop.
Thursday, April 23
Tietoteknia, TTA
9.15-12.00	Design and analysis of randomised complete block experiments, repeated measures experiments and cross-over experiments
Canthia, S9
13.00-17.00	Design and Statistics clinic
Friday, March 30
Tietoteknia, TTA
9.15-11.00	Assumptions and alternatives. Important assumptions. Transformations. Non-parametric tests. Covariates. Multiple comparisons. Common errors. David Lovell
Canthia, S9
12.00-14.00	Practical MINITAB exercises on day's topics David Lovell

Reference materials:

1. Michael F.W. Festing, Philip Overend, Rose Gaines Das, Mario Cortina Borja, Manuel Berdoy. The Design of Animal Experiments. Reducing the use of animals in research through better experimental design. Laboratory Animal Handbooks NO. 14. The Royal Society of Medicine Press Ltd, London 2002.
2. Michael F.W. Festing, David Dewhurst and Jane Broadhurst. Experimental Design. A Guide to using fewer experimental animals and getting the most out of your experiments. CD-disk. Sheffield Bioscience Programs 2001.
3. Experimental Design and Statistics in Biomedical Research. Special issue of ILAR Journal 43, Number 4, 2002.
4. Morton, D.B. (1998) The importance of non-statistical design in refining animal experimentation. ANZCCART Facts Sheet. ANZCCART News 11, No. 2 June 1998 Insert. pp12. Publrs. ANZCCART PO Box 19 Glen Osmond, SA5064, Australia.
5. Hendriksen, CFM & D. B. Morton. (1999). Eds Humane Endpoints in Animal Experiments for Biomedical Research. Proceedings of the Intnl Conference, 22-25 Nov 1998 Zeist, The Netherlands. pp 150. ISBN 1-85315-429-6 Publrs Royal Soc Med. London WIM 8AE
6. ILAR (2000) Humane Endpoints for Animals used in Biomedical Research and testing. ILAR Journal 41 No 2.

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